MANGANESE DEFICIENCY AFFECTS HDL 1 AND HDL 2 COMPOSITION IN RATS

Abstract

The effects of manganese deficiency on high density lipoprotein subclass (HDL 1 and HDL 2) composition was assessed. Weanling male Sprague-Dawley rats were fed a manganese-deficient (0.48 mg/kg) or a manganese-adequate (90 mg/kg) diet. After 15 weeks, mean body weights, liver manganese, plasma cholesterol and protein, and HDL 2 cholesterol and protein were significantly lower in the deficient group of rats. Plasma and HDL 2 phospholipids and triglycerides and HDL 1 protein and lipids were not significantly affected by manganese deficiency. The percentage of apolipoprotein A-I in HDL 1 was significantly greater (P < 0.05) in manganese-deficient rats, while the HDL 2 apolipoprotein composition was the same in both groups. The apparent molecular weights of apolipoproteins were not affected by manganese deficiency in either HDL subclass. © 1997 Elsevier Science Inc.