Abstract
Objective: To report a case of Multiple myeloma (MM) in mandible with paraesthesia. Material and Methods: The present case report highlights the occurrence of a swelling in the left posterior mandibular region in a 70-year old female patient and draws attention to the first clinical sign of a widespread systemic disease manifesting in the head and neck region. Results: The initial presumptive diagnosis was invalidated by the histopathological examination and other diagnostic tests that revealed the features characteristic for MM. Conclusion: Being a rare disease, MM should be kept on forefront of differential diagnosis for jaw lesions in a geriatric patient with paraesthesia.Keywords: Multiple myeloma; Mandible; Paraesthesia.
Highlights
Multiple myeloma (MM) is a relatively rare malignant hematological disease accounting for 1% of all cancers and slightly over 10% of all hematologic malignancies [1]
It is characterized by the multicentric proliferation of plasma cells in the bone marrow, an excessive amount of abnormal monoclonal immunoglobulins and CRAB symptoms which includes hypercalcemia, renal insufficiency, anemia, and bone lytic lesions [2,3]
Plasma cell neoplasms are B-cell lymphoid neoplasms classified as solitary bone plasmocytoma, multiple myeloma and extramedullary plasmacytoma
Summary
Multiple myeloma (MM) is a relatively rare malignant hematological disease accounting for 1% of all cancers and slightly over 10% of all hematologic malignancies [1] It is characterized by the multicentric proliferation of plasma cells in the bone marrow, an excessive amount of abnormal monoclonal immunoglobulins and CRAB symptoms which includes hypercalcemia, renal insufficiency, anemia, and bone lytic lesions [2,3]. Extra-oral examination revealed a diffuse painless swelling in the left mandibular posterior region which was bony hard in consistency, non-fluctuant, showing paraesthesia. Intra-oral examination showed bony hard swelling extending from permanent left mandibular canine to permanent left mandibular third molar region with obliteration of buccal vestibule and cortical expansion. The treatment was complicated by worsening respiratory conditions and patient expired three months later, despite treatment
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