Abstract
Creutzfeldt-Jakob disease (CJD) and a variant form, vCJD, are types of transmissible spongiform encephalopathies which are caused by abnormal, infectious prion proteins and lead to the degeneration of brain tissue. As vCJD is linked to the lymphoreticular system which includes the gastrointestinal tract, there is a possibility of transmission via a contaminated endoscope. Annette Puzey reviews the most recent advice on how to reduce the risk of transmitting prions to patients undergoing flexible endoscopy, considering patient assessment, the level of tissue infectivity, and the risk of invasive procedures.
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