Abstract
Our understanding of the mechanisms underlying coagulation have advanced rapidly in recent years. In addition, there are new methods to assess coagulation and new agents in the treatments of thromboembolic diseases such as atrial fibrillation, myocardial infarction and venous thromboembolism. It is particularly important for the neurosurgeon to be familiar with this topic in order to balance risks between bleeding and thrombosis in association with surgery. This review provides an overview of the ‘cell-based’ theory of coagulation and the technique of rotational thromboelastograpy to measure wholeblood coagulation. We discuss current management strategies related to haemorrhage control, haemostasis in polytrauma, and the elective and emergency peri-operative management of aspirin, thienopyridines, warfarin and the novel oral anticoagulants (rivaroxaban, dabigatran, apixaban). Finally, the current evidence regarding neurosurgical thromboprophylaxis is reviewed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Advances in Clinical Neuroscience & Rehabilitation
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
