Abstract
Since 2015, an epidemic of Zika virus spread across the Americas. This coincided with an increased incidence of microcephaly reported at birth in Brazil, with subsequent evidence of a causal association. Systemic reviews, observational studies, public health organizations. Zika virus causes microcephaly and brain abnormalities in infants born to mothers infected during or shortly before pregnancy. Zika virus is a trigger for Guillain Barre Syndrome. Whilst mosquito bite is the main route of transmission, sexual transmission is another confirmed route. Uncertainty remains regarding the proportion of Zika-infected pregnancies that will give rise to a significantly affected infant. The development of a vaccine remains a priority whilst public health efforts continue to educate at risk populations on reducing transmission. Follow-up studies of affected infants are vital to inform on prognosis and guide screening programmes of the future.
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