Abstract
IN A previous issue ofThe Journal(1982;247:671-674), the role of drug therapy in the control of ventricular tachyarrhythmias was explored. The discussion of this therapeutic approach continues, and two other broad categories of management, "pacing" and "surgery," are examined. Drug Therapy Role of Electrophysiological Studies and Serial Drug Testing.— In recent years, electrophysiological studies have been used in an attempt to achieve a more objective therapeutic end point for the control of ventricular tachyarrhythmias.1This has been made possible by the realization that ventricular tachyarrhythmias can be induced by programmed electrical stimulation (PES) in the controlled environments of the electrophysiology laboratory. This is particularly true of ventricular tachycardia (VT) and ventricular fibrillation (VF), both of which are generally reentrant in nature and, therefore, inducible with PES in a majority of patients who have experienced VT or VF or both. Programmed electrical stimulation is accomplished through electrode catheters (similar
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