Abstract

This study aimed to evaluate the outcome of patients with type 1 gastric neuroendocrine neoplasia (T1gNENs) treated with different endoscopic approaches. Patients were managed with endoscopic surveillance at regular intervals. Resection was performed by forceps or cold snare in tumours < 10mm, otherwise mucosal resection (EMR) or submucosal dissection (ESD) were done. 127 T1gNENs, detected in 80 patients, were included. 87.4% of them were <5mm, whereas 8.7% were 6-10mm, 3.1% were 11-20mm, and 0.8% was >20mm. Ki67 <3%% was found in 85.8% tumours, whereas it was 3%-20% in the remaining 14.2% lesions. Noninterventional management (surveillance without radical resection) was performed in 15 patients (18.7%) with T1gNENs <5mm. None of them underwent disease progression during follow-up. among the 65 patients treated by radical endoscopic resection, 37 patients (56.9%) had disease recurrence. 48.5% T1gNENs were removed by forceps, 16.8% by cold snare, 31.7% by EMR and 3% by ESD. The recurrence rate was similar among the different endoscopic techniques used. The management of T1gNENs may be planned based on tumour size. T1gNENs < 5mm for which the initial removal is not radical could be followed up by noninterventional endoscopic surveillance.

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