Abstract
Our knowledge of hypertension is at present at an awkward stage. The disease process is well enough known to make detailed investigation of the individual patient desirable, but not well enough understood to make the investigation easy Drug therapy is also at a complicated stage; autonomic control of the cardiovascular system has always been a happy hunting-ground for the pharmacologist, and we now have access to what must be the largest range of drugs that is available to any one particular condition. Yet these drugs are largely non-specific; most of them do not, as far as we know, correct any basic abnormality. Added to this is the fact that in treatment of hypertension we are dealing with a sensitive end-point, a fairly narrow range of blood pressure levels at which the patient feels comfortable and the doctor feels satisfied.
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