Abstract
The case of a young female patient with metachronous primary melanomas, advanced breast and pancreatic cancers is reported. The 5 different tumors diagnosed within six years, were managed with curative intent. Genetic analysis revealed the mutation of the R24P CDKN2A gene in a heterozygote form in both the patient and her father. Careful tertiary prevention during the follow-up of the patient is needed.
Highlights
The prevalence of multiple primary malignancies varies between 0.73% - 11.7% [1,2]
Genetic analysis revealed the mutation of the R24P CDKN2A gene in a heterozygote form in both the patient and her father
In cases with multiple malignant diseases manifested at a young age, the possibility of genetic predisposing factors responsible for the elevated cancer risk is considered
Summary
The synchronous occurrence of primary malignancies is uncommon, but metachronous primary tumors are diagnosed more frequently due to the longer survival of the population and the successful therapy of malignancies [3]. Depending on the time between the diagnosis of the individual malignancy, multiple primary malignancies can be divided into two categories. Synchronous cancers occur within 6 months, whereas metachronous multiple malignancies occur later than 6 months after the diagnosis of the first malignancy [4]. In cases with multiple malignant diseases manifested at a young age, the possibility of genetic predisposing factors responsible for the elevated cancer risk is considered. The detection of five different primary tumors within six years is quite rare. We report the case history of a young female patient with successfully treated malignant melanomas, breast and pancreatic cancers
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