Management of STIC lesions in risk-reducing bilateral salpingo-oophorectomy (RRBSO)

Abstract

Objective: Serous tubal intraepithelial carcinoma (STIC) is considered the precursor of many ovarian and primary peritoneal serous carcinomas in BRCA mutation-positive women. STIC are discovered incidentally in the fallopian tubes via risk-reducing salpingo-oophorectomy in approximately 5%–7% of women. Unfortunately, the biological and clinical relevance of these lesions in BRCA mutation-positive women is unknown. The purpose of this study was to review the incidence of STIC lesions in women undergoing risk-reducing salpingo-oophorectomy with a BRCA mutation compared to those without a mutation and their outcomes in follow-up.