Abstract

In developing countries, more than half of the anesthesia-related maternal deaths are related to spinal hypotension. To explore the practices of management of spinal induced hypotension with respect to fluid and vasopressor administration among anesthesiologists from a developing country. After approval from institutional ethics committee, an online questionnaire was sent to anesthesiologists registered with Pakistan Society of Anesthesiologists between July and August 2018 to determine management strategies for prevention and treatment of spinal-induced hypotension. The response rate was 36% (156/433), majority from academic institution (62.8%) with equal representation from attending and trainee anesthesiologist. For prophylaxis 39.1% respondents did not use vasopressors, 32.7% used fluid preloading with crystalloids (54.7%) as fluid of choice followed by combination of co-loading and vasopressor(22.4%). Phenylephrine was the vasopressor of choice for both prophylaxis (33.1%) and treatment (57%). Attending anesthesiologist used a combination of fluid co-loading and vasopressors for prophylaxis as compared to trainee anesthesiologists (37.2% vs. 17.9%; P=0.035) and selected vasopressors according to patient's heart rate (33.3% vs. 19.5%; p=0.05). Prophylactic phenylephrine was used more by respondents from the academic institution (p=0.023). Fluid co-loading was used more by respondents with <30 % compared to those with > 30% of clinical responsibility to obstetric anesthesia (P<0.05). Phenylephrine as the vasopressor of choice indicates growing awareness of management strategies among anesthesiologists from developing countries but there is a need to increase its use for prophylaxis. Some variation in practice according to the level of anesthesiologist, practice type and responsibilities to obstetric anesthesia are evident.

Highlights

  • Obstetric patients develop more extensive block following spinal anesthesia than non-pregnant patients.[1]

  • The results of this study showed that practice of prevention and treatment of spinal induced hypotension was different among respondents having less or more than 30% clinical responsibility to obstetric anesthesia

  • Considering the paucity of literature in developing countries, this study evaluates the practices of anesthesiologists from a developing country for prevention and treatment of spinal hypotension, in patients scheduled for elective caesarean section (CS)

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Summary

Introduction

Obstetric patients develop more extensive block following spinal anesthesia than non-pregnant patients.[1]. Researches in this field have led to the development of a recipe for prevention and management of hypotension following obstetric spinal anesthesia advocating phenylephrine as the first-line vasopressor.[4, 5] research advances in the developed world have not been translated into practical guidelines to reduce the unacceptable high maternal mortality rate present in resource-limited clinical settings. This is evident from the sixth report on the confidential enquiries into maternal deaths in South Africa where more than half of the anesthesia-related deaths were related to spinal hypotension, and almost all could have been prevented.[6] Considering high mortality from spinal hypotension, there is still a paucity of literature from developing countries.

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