Abstract

Sandhivata or Osteoarthritis is a degenerative joint disease. It is considered to be the result of inflammation, degeneration and wearing out of joint cartilage over time. Here the top layer of cartilage breaks down and goes away. This makes the bones under the cartilage to rub together. The rubbing results in pain, swelling and loss of motion of the joint. Sandhivata develops in all ages of people, but most probably it occurs after the age of 40. The most commonly affected joints include knee, hips, etc. Gradually O.A worsens as the time passes. Then the bone starts to break down and develops growths called spurs. There is a possibility to chip off the bits of bone or cartilage and float around in the joint. As a result of inflammatory process in the body, cytokines (proteins) and enzymes are produced that will further damage the cartilage. The primary purpose of this study was to establish the efficacy of medicines or treatment and demonstrate freedom from unwanted side effects in human. Suitable medicine plays a paramount role in the success of treatment as it is a main factor lying with the management of a disease. There is a direct proportional relationship between the success of treatment and the genuineness of the medicine. The present study was undertaken to carry out the clinical evaluation of Rasnashirishadi Kwatha and Ajamodadi Vati in Sandhivata patients.

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