Management of Primary Immune Thrombocytopenia in Pregnancy

Abstract

(N Engl J Med. 2023;389:540–548) Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immunoglobulin G antiplatelet antibodies that lead to reduced platelet production and increased platelet clearance. It affects 1 in 3 people per 10,000 in the United States. ITP is more common in women of childbearing age, and during pregnancy, platelet counts may decrease, requiring special medical attention. Immunoglobulin G antiplatelet antibodies can also affect the fetus. The clinical variability of ITP complicates diagnosis and treatment, and uncertainty remains for many aspects of management. This article focuses on recent research on the risk assessment and management of primary ITP.