Abstract
IntroductionLow-molecular-weight heparin (LMWH) is frequently recommended for the treatment of pregnancy associated venous thromboembolism (PAVTE). Given that prior reports have suggested a wide variation in dosing of LMWH in pregnancy and the use of anti-Xa monitoring in pregnancy, the principal aim of this survey was to assess current practices for the management of PAVTE.MethodsAn electronic survey was conducted. The target sample was members of the North American Society of Obstetric Medicine and Thrombosis Interest Group of Canada.ResultsThe final sample consisted of 27/69 hematologists (39.1%), 30/69 internists (43.5%), 8/69 obstetricians (11.6%), and 4/69 from other specialties (5.7%). For the acute treatment of patients pregnant patients with deep vein thrombosis 42/69 (60.8%) preferred LMWH given twice a day 42/69 (60.8%), whereas 25/69 (36.2%) preferred once daily. These results were similar for patients with pulmonary embolism (PE). For long-term treatment more than 70% of the respondents favoured treatment with full doses of LMWH given once a day or twice a day and 16/69 (23.2%) intermediate doses for patients diagnosed with DVT. These results were similar for patients with PE. Fourteen physicians out of 69 (20.3%) did not measure anti-Xa monitoring during acute treatment period and 24/69 (34.8%) never used anti-Xa levels during the long term treatment period. Management during the peri-partum period varied widely according to the time of the diagnosis of PAVTE.DiscussionIn conclusion, our survey shows wide variation in practice regarding LMWH dosing and anti-Xa monitoring in pregnancy associated VTE and calls for trials comparing different long term strategies using LMWH in patients with PAVTE.
Highlights
Low-molecular-weight heparin (LMWH) is frequently recommended for the treatment of pregnancy associated venous thromboembolism (PAVTE)
For the acute treatment of pregnant patients with deep vein thrombosis (DVT), 42/69 (60.8%) preferred LMWH given twice a day whereas 25/69 (36.2%) prescribed it once daily. These results were similar for patients with pulmonary embolism (PE), 6% of the respondents favored Unfractioned heparin (UFH) for the initial treatment period
Our survey suggests that LMWH is the preferred drug for the management of PAVTE but that there is wide variation in dosing strategies and the use of anti-Xa monitoring
Summary
Given that prior reports have suggested a wide variation in dosing of LMWH in pregnancy and the use of anti-Xa monitoring in pregnancy, the principal aim of this survey was to assess current practices for the management of PAVTE. Low-molecular-weight heparin (LMWH) is frequently recommended for the treatment of pregnancy associated venous thromboembolism (PAVTE) [1]. Normal physiologic changes occurring during pregnancy affect the pharmacokinetics of LMWH that result in increasing dose requirements in pregnancy (due to a greater volume of distribution and increased renal clearance) [2]. In patients with PAVTE a more aggressive approach using continuous full doses of LMWH, given twice daily and tailored to anti-Xa levels is commonly
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