Abstract
Myo-Inositol and D-chiro-inositol (MI-DCI) are used in the treatment of polycystic Ovary syndrome (PCOS) due to their insulin-sensitizing actions. Therefore, it is of interest to evaluate the treatment patterns, clinical effectiveness and safety of MI-DCI combination in anagement of PCOS in Indian women. Data from 50 healthcare centers across India was collected between September 2019 and February 2020 and was used in the study. Women aged 12-45 years diagnosed with PCOS, who had received MI-DCI (550-150 mg) were included. The outcome parameters were change in weight, luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratio, hirsutism, blood glucose and insulin levels, HOMA-IR, and lipid profile. A total of 283 women were included (mean age: 27.74 years; body mass index: 26.89 kg/m2); of which 197 (69.61%) reported reduction in weight after treatment with MI-DCI. The hirsutism scores considerably improved after treatment and the proportion of patients with, no hirsutism increased from 31.07% to 50.51% and moderate hirsutism reduced from 32.52% to 6.12% while, there were no patients with severe hirsutism after the treatment. There was a significant reduction in LH:FSH ratio (mean difference: 0.25 mg/dL; p=0.021), free testosterone (mean difference: 1.49; p<0.001) and dehydroepiandrosterone (mean difference: 21.49; P<0.001) levels after regular use of MI-DCI tablets. Treatment with MI-DCI resulted in significant improvement in insulin levels, HOMA-IR score, Fasting plasma glucose (FPG), post-prandial plasma glucose (PPG) and lipid profile. The therapy restored menstruation and spontaneous ovulation and significantly attenuated the LH/FSH ratio. Thus, MI-DCI (550-150 mg) has shown multidimensional benefits in improving the hormonal, glycemic, and lipid profile of women with PCOS with considerable efficacy and tolerability.
Highlights
Polycystic ovarian syndrome (PCOS) is a complex and heterogeneous endocrine disorder characterized by a constellation of symptoms and clinical features, including hyper androgenism, ovulatory dysfunction, and polycystic ovarian morphology [1]
Clinical characteristics: A total of 283 patients with confirmed PCOS were included in this study
The most commonly associated clinical abnormalities observed in patients with PCOS were oligomenorrhea (75.27%), infertility (65.02%), hirsutism (49.12%), and acne (42.76%)
Summary
Polycystic ovarian syndrome (PCOS) is a complex and heterogeneous endocrine disorder characterized by a constellation of symptoms and clinical features, including hyper androgenism, ovulatory dysfunction, and polycystic ovarian morphology [1]. Almost 65–70% of women with PCOS are affected by insulin resistance and compensatory hyper insulin-emia [2]. The latter together with beta-cell dysfunction considerably increases the risk of developing other metabolic abnormalities such as type 2 diabetes (T2D), hypertension, dyslipidemia, and cardiovascular diseases [1]. The therapeutic basis for the use of inositols in PCOS lies in their insulin-sensitizing potential and the beneficial metabolic effects [3]. Indian data regarding the use of high concentration of DCI for PCOS treatment is scarce. It is of interest to evaluate the treatment patterns, clinical effectiveness and safety of MI and DCI combination (550/150 mg) in management of PCOS among Indian women
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