Abstract
Introduction: Management of pheochromocytoma faces different challenges leading to misdiagnosis and therapeutic delay in developing countries. The aim of our study was to evaluate the diagnostic and therapeutic features as well as the evolution of our management strategies in hospital setting in recent years in Dakar. Patients and Method: We carried out a retrospective study over 12 years (January 2005 to June 2017), in 4 hospitals in Dakar. We only included patients with established diagnosis of pheochromocytoma upon clinical, biological, radiological and histological arguments. Results: During this period, 16 observations have been collected and were all about female patients. The mean age at the time of diagnosis was 36.81 years. The clinical signs were dominated by hypertension found for 14 patients. At biological examination, hypersecretion catecholamine was found in 13 patients, high urinary metanephrines in 7 patients, high plasmatic metanephrines in 2 patients and raised urinary Vanyl Mandelic Acid (VMA) in 4 patients. Dosage of chromogranin A showed high level for one patient. Abdominal CT scan allowed making the adrenal origin of tumors precise. One patient presented bilateral pheochromocytoma. Before being treated surgically, all patients had had medical preparation. The surgical treatment by median laparotomy consisted of an enucleation of the tumor in 2 patients, and adrenal resection in 11patients.The evolution after surgery was favorable in 12 patients out of 13. One patient died 2 days after surgery by hemodynamic instability. In 2 patients who presented metastases, multidrug therapy with cyclophosphamide, vincristine and dacarbazine was decided after a multidisciplinary meeting, but they died before treatment. Conclusion: Management of pheochromocytomas in developing countries is obviously improving, but the mortality rate remains high. Early diagnosis and perioperative care are to be targeted for better outcome and prognosis of this rare tumor in our areas.
Highlights
Management of pheochromocytoma faces different challenges leading to misdiagnosis and therapeutic delay in developing countries
Hypersecretion catecholamine was found in 13 patients, high urinary metanephrines in 7 patients, high plasmatic metanephrines in 2 patients and raised urinary Vanyl Mandelic Acid (VMA) in 4 patients
The surgical treatment by median laparotomy consisted of an enucleation of the tumor in 2 patients, and adrenal resection in 11patients.The evolution after surgery was favorable in patients out of
Summary
Pheochromocytoma is a rare tumour of adrenal gland’s medulla leading to an excessive secretion of catecholamines [1]. Paroxysmal hypertension associated with Menard’s triad is the most usual mode of revelation. The first step of the diagnosis consists in highlighting the catecholamine hypersecretion by dosage of the plasmatic or urinary metanephrines [1]. Pheochromocytomas are usually benign tumours; its malignity as for all neuroendocrine tumours is defined by existence of distant metastases [2]. Pheochromocytomas are under diagnosed in occident where 0.05% to 0.1% are discovered at the time of autopsies [3] [4]. The aim of our study was to evaluate the diagnostic and therapeutic features of pheochromocytomas in our practice, as well the evolution of our management strategies in hospital setting in recent years in Dakar
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