Abstract
Background: Spinal cord trauma has a negative prognosis, with low life quality. Management procedures increase chances of survival and a better life quality. Objectives: Review in the scientific literature which treatments are recommended to spinal cord trauma in the hospital and how it affects life quality. Methods: A literature review was carried out in the MEDLINE/Pubmed, Scientific Electronic Library Online (SciELO) and LILACS databases, using the terms “spinal trauma”, “recovery”, “patient management”, “accessibility” and “life quality”, in Portuguese, English and Spanish. 87 articles were found and 15 followed for complete analysis. This exclusion criteria were used: (a) articles published before 2015; (b) articles that did not fit the proposed theme. Results: At the hospital, treatment to spinal cord trauma is supportive, reducing secondary damage. Respiratory disorders are treated with intubation. Management of the respiratory tract should also include physiotherapy of the pectoral region, secretion clearance, mucolytic and bronchodilators. High-risk patients may need tracheostomy. The more complex the injury and the higher the level, the more aggressive the neurogenic shock. The first treatment should be fluid resuscitation, to maintain euvolemia. The second, vasopressors and inotropes. MAP should be above 85-90 mmHg during the first week to avoid neurological damage. Conclusions: The treatments are extremely important, but the prognosis is usually negative, given the limitations that reduce the life quality of these people, who suffer from a lack of accessibility.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
Objectives: The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
The analyses showed significantly higher frequency of the genotype VV in those who had depression, compared with the allele A
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Neuroinfections are pathologies that affect the CNS, for example, we have Murcomycosis, a progressive infection caused by opportunistic fungi of the order Mucorales, with high frequency in Immunodepressed patients, Diabetes Mellitus (DM) is the main underlying pathology associated with the development of Rhinocerebral Murcomycosis, which represents 50% of the cases, with a mortality rate of 70% (Sidrim, 2012, p.168). The COVID-19 pandemic has been alarming the world since its first outbreak in December 2019 In this scenario, the presence of aggravating factors such as the elevation of the D-dimer and the reduction of the angiotensin-converting enzyme 2 (ACE2) during the clinical course of the disease, collaborated in the appearance of thromboembolic events derived from inflammatory processes and extensive intravascular coagulation, contributing to the emergence of diseases such as Hemorrhagic Stroke (ICH), leading the patient to have a worse clinical prognosis and a consecutive worsening of their health. Despite being classically associated with this etiology, the finding may be present in other diseases, especially infiltrative ones
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