Abstract

In the older population, especially the hospitalized patients who are prone to dehydration and hypovolemia, orthostatic hypotension (OH) presents as a debilitating disease. How different pharmacological and non-pharmacological interventions affect the incapacitating symptoms (falls and episodes of syncope), morbidity, and mortality related to OH has become a topic of debate. OH can predispose to ischemic heart disease (IHD). A non-pharmacological approach consisting of mobilization, early lifestyle changes, and therapeutic maneuvers is the first choice in the management of these patients. Individuals with persistent symptoms require pharmaceutical therapy to increase blood volume and peripheral vascular resistance. This article summarizes the management of OH that is vital to cope with the needs of the growing geriatric populations.

Highlights

  • BackgroundOrthostatic hypotension (OH) is characterized by a sustained decrease in blood pressure (BP) on standing

  • Especially the hospitalized patients who are prone to dehydration and hypovolemia, orthostatic hypotension (OH) presents as a debilitating disease

  • How different pharmacological and nonpharmacological interventions affect the incapacitating symptoms, morbidity, and mortality related to OH has become a topic of debate

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Summary

Introduction

Orthostatic hypotension (OH) is characterized by a sustained decrease in blood pressure (BP) on standing. An upright posture leads to pooling of 500-1000 ml of blood in the lower extremities and splanchnic and pulmonary circulations [12] This leads to a drop in the systolic and diastolic pressures, with the reduction of venous return to the heart, decreased ventricular filling, and transient descent of the afterload. Through compression garments for abdominal and lower extremities, allows reduction of venous stasis and thereby orthostatic arterial hypotension, especially in the elderly patients At their maximum efficiency, these external compression garments are able to handle pressures ranging between 15 and 40 mmHg [17]. To treat and prevent OH in hospitalized older patients, early mobilization and avoidance of physical deconditioning are recommended [18] In these patients, simple positional changes play a vital role in improving OH without medications. Pharmacological therapy focuses on either increasing blood volume or raising peripheral vascular resistance

Increasing blood volume
Increasing peripheral vascular resistance
Conclusions
Disclosures
Gore JM

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