Management of obesity and other metabolic disorders through faecal microbiota transplant technology

Abstract

The microbiota regulates health and many diseases both infectious and metabolic. The makeup and density of intestinal microbiota can be influenced by diet and therefore, they play a major role in the development of obesity by regulating energy metabolism. Recent evidence, primarily from investigations from animal models, suggests that the gut microbiota affects nutrient acquisition and energy regulation. Gut microbiota regulates obesity by regulating energy absorption, central appetite, fat storage, chronic inflammation, and circadian rhythms. Several members of phylum Proteobacteria, were reported to be obesity-associated. Among non-antibiotic therapeutic method, the faecal microbiota transfer technology seems to be one of the effective therapeutic and management techniques to treat and/or manage some of the metabolic disorders in particular obesity.