Abstract

Non-alcoholic fatty liver disease (NAFDL) includes fatty liver or simple steatosis, characterized by lipid deposits in hepatocytes and more advanced stages such as steatohepatitis (NASH) and non-alcoholic cirrhosis. Physical inactivity, hypercaloric and unbalanced diet together with aging play a key role in the pathogenesis of NAFLD and are strongly associated with metabolic and physical activity continue to be major components in prevention and first-line treatment to attenuate or reverse NAFLD. Dietary patterns, their composition and weight reduction would be the most relevant nutritional aspects in NAFDL treatment. Physical exercise, moderate to intense, aerobic and resistance type contributes to weight loss, improves metabolic control and body composition. Pharmacological therapy can be useful in clinical circumstances that require it and needs a medical evaluation when there is no adherence and success in non-pharmacological interventions.

Highlights

  • Análisis crítico del tratamiento de la enfermedad hepática grasa no alcohólica Fabian Lanuza1,3,a, Jorge Sapunar[2,3], Edmundo Hofmann[2]

  • Moderate to intense, aerobic and resistance type contributes to weight loss, improves metabolic control and body composition

  • Pharmacological therapy can be useful in clinical circumstances that require it and needs a medical evaluation when there is no adherence and success in non-pharmacological interventions. (Rev Med Chile 2018; 146: 894-901) Key words: Non-alcoholic Fatty Liver Disease; Diet; Exercise; Pharmacology

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Summary

Fisiopatología y mecanismos involucrados

La fisiopatología del EHGNA es compleja e involucraría distintos mecanismos (Tabla 1).

Disminución en la excreción de VLDL
Rol de la dieta en la enfermedad hepática grasa no alcohólica
Por diferencia
Rol del ejercicio en enfermedad hígado graso no alcohólico
Intervención farmacológica
Ácido Ursodeoxicólico Ácido Obeticólico
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