Management of massive and persistent ascites and/or hydrothorax after liver transplantation

Abstract

PurposeTo describe the results of the treatment of eight liver transplantation (LT) patients subsequently developing large volumes of long-lasting ascites. Patients and methodsBetween August 1996 and February 2003, 405 LTs were performed in 375 patients, eight (1.97%) of whom (six men and two women of mean age of 55.4 ± 5.2 years) subsequently developed massive (> 500 mL/d) and persistent ascites and/or hydrothorax. All patients were HCV positive. The mean age of the liver donors was 66.8 ± 21.9 years. All LTs were performed by replacement of the recipient retrohepatic vena cava. ResultsThe eight patients displayed sinusoidal portal hypertension related to biopsy-proven recurrence of HCV infection. Mean wedged hepatic venous pressure was 14.9 ± 5.1 mm Hg and mean portal vein/right atrial pressure gradient (PAPG) was 17.3 ± 4.8 mm Hg. In two patients, the ascites appeared the day after LT; in the remaining six, ascites and/or hydrothorax appeared after 342.3 ± 167.7 days. Seven patients with a mean PAPG of 18.4 ± 3.9 mm Hg and a mean plasma/ascites albumin concentration gradient of 2.8 ± 0.3 g/L were treated by means of a trans-jugular intrahepatic portosystemic shunt TIPS, and one (with a PAPG of 9 mm Hg and a plasma/ascites albumin concentration gradient of 1.38 g/L) by means of spleen arterial embolisation. After a mean follow-up of 558 ± 147.2 days, the ascites and/or hydrothorax have resolved in five patients (62.5%), one (12.5%) has stable ascites not requiring paracentesis, and two (25%) have died of multiorgan failure. ConclusionThese data suggest the efficacy of the aggressive treatment of massive and persistent ascites and/or hydrothorax.