Abstract
Background: We report a case of a male patient in our hospital who developed associated multidrug-resistant Acinetobacter baumanii (MDRAB) intracrainial ventriculitis and treated using intraventricular (IVT) plus intrathecal (IT) colistin.
 Objective: The purpose of our case report is to show case the effectiveness and safety of using intraventricular (IVT) plus intrathecal(IT) colistin in the management of potentially fatal MDRAB associated intracrainial ventriculitis.
 Materials and methods: Patient was diagnosed with MDRAB after developing associated symptoms and conducting cerebral spinal fluid (CSF) culture and sensitivity analysis. Colistin 250,000 IU once daily administered via intraventricular plus intrathecal routes for 14 days was prescribed.
 Result: Cerebrospinal fluid was collected on the 14th day post commencement of colistin and sterilization was attained.
 Conclusion: Colistin is a potentially effective and safe therapy for the treatment of MDRAB intracrainial ventriculitis.
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