Abstract
Treatment approaches for metastatic brain tumors continue to evolve, with increasing recent emphasis on focal therapies whenever possible. MRI-guided Laser Interstitial Thermal Therapy (LITT) is a minimally invasive surgical option that has broadened the capability of the neurosurgeon in treating difficult-to-treat intracranial lesions. This technology uses image-guided delivery of laser to the target lesion to generate heat and thereby ablate pathological tissue and has expanded the neurosurgical armamentarium for surgical treatment of brain metastases. In this study, we describe the indications for LITT in the management of intracranial metastatic disease and report our institutional experience with LITT.
Highlights
Current strategies for the treatment of metastatic brain tumors include surgical resection or ablation, stereotactic radiosurgery, fractionated radiation therapy, whole brain radiation therapy (WBRT), and in select cases, targeted medical therapy
We describe our institutional series of 25 cases of intracranial metastatic disease treated with Laser Interstitial Thermal Therapy (LITT)
A total of 25 LITT cases were performed for metastatic brain tumors on 24 patients between September 2010 to April 2016 at Washington University in St
Summary
Current strategies for the treatment of metastatic brain tumors include surgical resection or ablation, stereotactic radiosurgery, fractionated radiation therapy, whole brain radiation therapy (WBRT), and in select cases, targeted medical therapy. Recent data indicate that rather than performing WBRT, more focused and localized treatment of brain metastases using stereotactic radiosurgery (SRS) might be favorable due to cognitive issues associated with WBRT [1]. These results raise the general concept that focal therapies, where possible, should be preferentially considered for brain metastases. Hazard ratio (HR) with 95% confidence interval was calculated from Cox proportional hazard model
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