Management of Huntington’s Disease by Faecal Microbiota Transplant (FMT) Technology

Abstract

Huntington's disease (HD) is an inherited autosomal dominant neurodegenerative disorder in which nerve cells in the brain break down over the time. Huntington's disease results in a decline in thinking and reasoning skills, including memory, concentration, judgment, and ability to plan and organize. Brain changes in this disease lead to alterations in mood, especially depression, anxiety, uncharacteristic anger and irritability. Unfortunately, no cure exists, but drugs, physiotherapy and talk therapy can help to manage some symptoms. Bidirectional communication between the gut microbiome and central nervous system via gut-brain axis gives a clue that dysbiosis of the gut microbiota in HD is the causal factor for the prognosis of the disease. Promising results were obtained from Faecal Microbiota Transplant (FMT) treatment in human trials and animal models are discussed here. The intensity of the symptoms could be reduced by FMT