Abstract
Introduction: Frailty is a geriatric syndrome characterized by a diminished physiological reserve of multiple organs, which means increased of vulnerability of older people to adverse outcomes. As the process which leads to frailty can be decelerated or even completely reversed, early prevention interventions are crucial.
 Methodology: A systematic literature search was conducted in the following databases: PubMed, Cochrane, Embase, Cinahl and UpToDate. The criterion in selecting the literature was that articles were published from 2002 to 2017. From 391.910 initial hits, 31 publications were selected.
 Results: Early diagnosis of frailty and functional decline are considered effective measures against age-related comorbidities. Targeted interventions have a significant impact on preventing the progression of frailty and the negative consequences of frailty. Lifestyle, including physical activity (particularly resistance exercise) and nutrition (higher protein intake and vitamin D supplement), is a good measure for preventing disorders associated with age.
 Conclusion: Targeted interventions have a significant modifiable influence on preventing frailty. Frailty management and early interventions comprise comprehensive and multidisciplinary approach including clinical management with physical management, nutrition and drugs.
Highlights
Frailty is a geriatric syndrome characterized by a diminished physiological reserve of multiple organs, which leads to greater risks of adverse outcomes in the elderly
Lifestyle, including physical activity and nutrition, is a good measure for preventing disorders associated with age
Knowledge of the complexity of determinants of frailty can assist the formulation of measures for prevention and early intervention, thereby contributing to a better quality of life for the elderly and greater dignity
Summary
Frailty is a geriatric syndrome characterized by a diminished physiological reserve of multiple organs, which leads to greater risks of adverse outcomes in the elderly. Frailty is a progressive age-related decline in physiological systems that results in decreased reserves of intrinsic capacity, which confers extreme vulnerability to stressors and increases the risk of a range of adverse health outcomes (World Health Organization, 2015). It can be viewed as poor resilience since it increases an individual's vulnerability to disproportionate changes in the health status and associated increased dependency and/or mortality when exposed to a stressor (Clegg, 2013). Lifestyle and other interventions may help offset the toll of ageing
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