Management of epileptic foci in patients with dysembryoplastic neuroepithelial tumor

Abstract

Objective To investigate the management of drug-resistant epilepsy in patients with dysembryoplastic neuroepithelial tumor (DNT). Methods Surgical experiences of 14 patients with DNT in our hospital were retrospectively reviewed. According to the EeoG during the operation and preoperative evaluation, the epileptic foci were managed when the tumor resection was performed. Results The tumors were cut off completely in all the patients; no radiotherapy or chemotherapy was performed after the operation; no recurrence or metastasis of the tumor was found. Engel Ⅰ outcome (seizure-free) was noted in 11 patients and Engel Ⅱ outcome (rare seizure) was noted in 2; frequent seizure was found in 1 after the first operation and seizure-free was achieved after the resection of epileptic foci around the tumor. Conclusion The DNT should be treated as having malformation in the cortical dysplasia and management of epileptic foci around the tumor shows favorable results in the controlling of epilepsy. Key words: Dysembryoplastic neuroepithelial tumor; Intractable epilepsy; Surgery; Malformation in the cortical dysplasia