Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosaL.) and Corosolic Acid

Toshihiro Miura,Torao Ishida,Satoshi Takagi

doi:10.1155/2012/871495

Toshihiro Miura, Torao Ishida + Show 1 more

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https://doi.org/10.1155/2012/871495

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Abstract

Banaba (Lagerstroemia speciosa L.) extracts have been used for many years in folk medicine to treat diabetes, with the first published research study being reported in 1940. This paper summarizes the current literature regarding Banaba and its constituents. The hypoglycemic effects of Banaba have been attributed to both corosolic acid as well as ellagitannins. Studies have been conducted in various animal models, human subjects, and in vitro systems using water soluble Banaba leaf extracts, corosolic acid, and ellagitannins. Corosolic acid has been reported to decrease blood sugar levels within 60 min in human subjects. Corosolic acid also exhibits antihyperlipidemic and antioxidant activities. The beneficial effects of Banaba and corosolic acid with respect to various aspects of glucose and lipid metabolism appear to involve multiple mechanisms, including enhanced cellular uptake of glucose, impaired hydrolysis of sucrose and starches, decreased gluconeogenesis, and the regulation of lipid metabolism. These effects may be mediated by PPAR and other signal transduction factors. Banaba extract, corosolic acid, and other constituents may be beneficial in addressing the symptoms associated with metabolic syndrome, as well as offering other health benefits.

Highlights

Banaba (Lagerstroemia speciosa L.) has been used as aE folk medicine to treat diabetes in various parts of the world, primarily southeast Asia
This paper summarizes studies that have been conducted in animals, humans, and in vitro systems on acid (Figure 1) which is isolated with an organic solvent the antihyperglycemic, antihyperlipidemic, and antioxidant from the leaves of the plant, and corosolic acid is used to activities of Banaba extracts, corosolic acid-standardized standardize Banaba extracts [1, 2]
In a study published by Tsuchibe et al [22], 12 nondiabetic subjects with a baseline blood glucose level of 104 mg/dL were given a soft gel capsule daily for 2 weeks containing 10 mg corosolic acid as a Banaba extract standardized to 18% corosolic acid

Summary

Introduction

E folk medicine to treat diabetes in various parts of the world, primarily southeast Asia. Most studies have focused on corosolic [12, 13], Glechoma longituba [14], Potentilla chinensis [15], Rubus biflorus [16], and Phlomis umbrosa [17] Many of these plants are native to Asia, corosolic acid has been isolated from European and South American plants. This paper summarizes studies that have been conducted in animals, humans, and in vitro systems on acid (Figure 1) which is isolated with an organic solvent the antihyperglycemic, antihyperlipidemic, and antioxidant from the leaves of the plant, and corosolic acid is used to activities of Banaba extracts, corosolic acid-standardized standardize Banaba extracts [1, 2]. At the end of 12 weeks, the subjects had lost an average of 6.29 kg (13.8 lb) including

D HO Figure 1

Animal Studies

C Various animal studies have subsequently shown that

In Vitro Studies

Findings

Conclusions