Abstract
Objective:To increase the use of evidence-based approaches in the diagnosis, investigations and treatment of Convulsive Status Epilepticus (CSE) in children in relevant care settings.Method:A Clinical Practice Guideline (CPG) adaptation group was formulated at a university hospital in Riyadh. The group utilized 2 CPG validated tools including the ADAPTE method and the AGREE II instrument.Results:The group adapted 3 main categories of recommendations from one Source CPG. The recommendations cover; (i)first-line treatment of CSE in the community; (ii)treatment of CSE in the hospital; and (iii)refractory CSE. Implementation tools were built to enhance knowledge translation of these recommendations including a clinical algorithm, audit criteria, and a computerized provider order entry.Conclusion:A clinical practice guideline for the Saudi healthcare context was formulated using a guideline adaptation process to support relevant clinicians managing CSE in children.
Highlights
Introduction to the GI-N Adaptation Working Group — Guidelines International Network [Internet]
There are no data on the prevalence of Status epilepticus (SE) in the Kingdom of Saudi Arabia (KSA), SE in children has been identified as a high priority health topic at the King Saud University Medical City (KSUMC) based on hospital records
We present a case illustration of the Clinical Practice Guideline (CPG) adaptation process for management of clonic seizures (CSE) in Saudi Arabia
Summary
The Guideline adaptation group (GAG) utilized 2 CPG validated tools: the ADAPTE methodology (version 2.0), with some modifications and the AGREE II instrument.[9,12,16] The ADAPTE consists of 3 phases. Phase 2 (Adaptation) consisted of defining clinical questions (PIPOH), identifying inclusion /exclusion criteria to search and screen source CPGs, appraising retrieved CPGs by the Appraisal of Guidelines for Research and Evaluation Instrument II (AGREE-II), and selecting from the appraised CPGs to be drafted into the finalized, adapted CPG. The AGREE-II is a validated assessment tool for the quality of CPGs, The AGREE-II includes 6 domains, namely (i) scope and purpose, (ii) stakeholder involvement, (iii) rigor of development, (iv) clarity and presentation, (v) applicability, and (vi) editorial independence.[16] Phase 3 (Finalization) included external review of the clinical content and methodology of the adapted CPG, planning for future reviews and updates, and final production of the adapted CPG with implementation tools
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