Abstract
BackgroundGiven the increasing number and survival rates of reproductive-age patients with chronic myeloid leukemia (CML), several studies aimed to elucidate optimum disease management in pregnancy. This study aimed to use bibliometric analysis to assess focus and reported insights, as well as future trends, in CML and pregnancy research.MethodsWe extracted all studies related to CML and pregnancy from the Web of Science database from 2001 to 2020. VOS Viewer, CiteSpace, Python, and R-bibliometrix were used for bibliometric analysis, revealing the leading research countries, institutions, and authors, as well as distribution of keywords (frequency greater than five).ResultsA total of 196 records, published in 137 journals by 1,105 authors from 421 research institutes in 50 countries, were identified for analysis. The United States was the leader in the number of publications. Imperial College London and National Research Center for Hematology were the most influential institutions. In addition, Apperley J, Cortes J, Abruzzese E and Kantarjian H were the leading authors in the field. Keyword analysis identified four research hotspot clusters.ConclusionsThis study systematically analyzed the progress in CML and pregnancy research in the last 20 years. The present findings suggest that the management of planned and unplanned pregnancies in patients with CML will remain a research focus, as further evidence is required for the development of treatment guidelines.
Highlights
Chronic myeloid leukemia (CML) is a malignant clonal disease originating from hematopoietic stem cells characterized by the production of large numbers of myeloid cells at various stages of maturation in peripheral blood
Chronic Myeloid Leukemia and Pregnancy improved survival in CML; most patients treated with imatinib achieve normal life expectancy, with some patients achieving sustained treatment-free remission (TFR) [3]
This study aimed to conduct a comprehensive bibliometric analysis of research literature published on CML and pregnancy over the past 20 years
Summary
Chronic myeloid leukemia (CML) is a malignant clonal disease originating from hematopoietic stem cells characterized by the production of large numbers of myeloid cells at various stages of maturation in peripheral blood. Chronic Myeloid Leukemia and Pregnancy improved survival in CML; most patients treated with imatinib (a type of TKI) achieve normal life expectancy, with some patients achieving sustained treatment-free remission (TFR) [3]. As the age of diagnosis decreases and survival improves, there is a need for effective CML management in pregnancy. Given the increasing number and survival rates of reproductive-age patients with chronic myeloid leukemia (CML), several studies aimed to elucidate optimum disease management in pregnancy. This study aimed to use bibliometric analysis to assess focus and reported insights, as well as future trends, in CML and pregnancy research
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