Abstract

Medical management of chronic idiopathic thrombocytopenia (ITP) in childhood often fails [20, 26], which is why splenectomy is the recommended method of choice in these cases. However, surgery may not guarantee permanent therapeutic effects either: removal of the spleen may be accompanied by an increased risk of postsplenectomy infections (overwhelming post-splenectomy infection, OPSI syndrome). For these reasons we carried out partial splenic resection in nine children with chronic ITP. The aim of this procedure was to influence the course of chronic ITP by saving the immunological competence of children. Results from a clinical, hematological, and immunological point of view are discussed.

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