Abstract
The neglected tropical disease amebiasis, caused by Entamoeba histolytica, is considered a threat to public health. Combinatorial approaches could identify more efficient and less costly alternatives in managing the second leading parasitic disease worldwide. Aggregative signaling and metabolic pathways, two distinct biochemical strategies, are being explored. 1) In vitro identification of chemicals secreted for cellular communication could be manipulated to prevent pathogenesis. 2) An essential enzyme in the glycolytic pathway, Entameba histolytica alcohol dehydrogenase 2 (EhADH2), provides a novel target for anti‐amebic drugs. Several synthetic pyrazoline derivatives and a commercial iron chelator were capable of restricting amebic growth via blocking EhADH2 activities. A holistic understanding of an infective agent could contribute to an improved management of infectious diseases based on ecological and evolutionary principles.
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