Abstract
Mammary Tumours in Hybrid Mice: the Presence and Transmission of the Mammary Tumour Agent
Highlights
BROTHER X SISTERI.-Scheme of breeding from tumour-bearing and tumour-free hybrids
Of the 23 tumours found in BR P, hybrids with normalR3 fathers, 20 were first seen in rnice less than a year old, the average age at detection being 38 weeks' The incidence in BR F, hybrids with agent-free R3 fathers is much lower or much later
The sex-limited transplantation described in a previous paper was not pecuhar to BR F 1 hybrids ; as recorded in the paper which follows (Foulds, 1949a), some tumours in the reciprocal RB F 1 hybrids, which had a high incidence of tumours, behaved
Summary
I.-Scheme of breeding from tumour-bearing and tumour-free hybrids. Mouse BR6 was mated with a sibling male to provide the F2 generation in the strain BR6. Male No, I sired the tumour-free female to start the strain BR 1 6. Selected F4females raised one or more litters to continue the strains, but MoSt F4 females were subjected to forced breeding throughout their reproductive lives. Selective breeding in the F4 generation established " wild," " white " and AGENT IN MAMMARY TUMOURS IN HYBRID NaCE. The " effective total "' is the number of mice which surv-ived to the age at which the earfiest tumour was detected in any of the groups, namely I 10 days in an F4 mouse of strain BR4 (blue label).
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