Mammary tumour incidence in relation to age and number of litters in C3Hf and RIIIf mice.

B D Pullinger,S Iversen

doi:10.1038/bjc.1960.31

Abstract

Mammary Tumour Incidence in Relation to Age and Number of Litters in C 3 H f and RIII f Mice

Highlights

I hybrids of 057 mothers and Rlllb fathers, together with an overall reduction in mammary carcinoma from 80 to less than 3 per cent in breeders and from 69 per cent to nil in virgin females through 34 generations allowed the presumption that the agent had been excluded from all sublines
The overall incidence amounted to 14 mammary carcinomas in 544 breeders in 18 generations (Table 1)
The 14 RIII, mammary tumours were less readily typed according to the description by Dunn (1959) than were those in C3H, mice

Summary

Introduction

REFERENCE data in respect of age, number of litters and mammary carcinoma incidence in C3Hf/He and RIIIf/Pu mice have been recorded and analysed quantitatively for the purpose of eventual comparison with results from substituted ovarian hormones. This substrain was derived by Caesarian section and cross-suckling from Andervont's C3H line (Andervont and McEleney, 1941) in which mammary tumour incidence was higher in virgin females than in breeders. The overall incidence amounted to 14 mammary carcinomas in 544 breeders in 18 generations (Table 1).

Results

Conclusion