Abstract
BackgroundMammary gland tumors are the most common tumors in sexually intact female dogs; however, they are rare in male dogs. This study was conducted to investigate the relationship between sexual hormones and mammary gland tumors in a male dog.Case presentationA 13-year-old, intact male Cocker Spaniel presented to the Veterinary Teaching Hospital of Kangwon National University, Republic of Korea, with an acute right ruptured caudal abdominal mass. Physical examination revealed a 14 × 14 cm ruptured mass in the right caudal abdomen, as well as a 1.5 × 1.5 cm mass in the first right mammary gland. The estrogen and progesterone concentrations in serum were within normal levels. Total mastectomy was done on the right side mammary glands. Following surgery, the site was fully recovered; however, a mass that had grown to 2 × 2 cm was found in the left fifth mammary gland and a testis tumor was also found over the period of 4 months. Mastectomy was performed on the left caudal mammary gland and castration was also performed. After the final surgery, the dog fully recovered. Histopathological examination of all three masses revealed high grade mammary adenocarcinoma in the mammary gland and the testis was diagnosed as Leydig cell adenoma. Immunohistochemical analysis revealed that the estrogen and progesterone receptors were expressed on limited cells in mammary and testis tumors.ConclusionThe results of this study suggest that mammary tumors and testes tumors can occur in male dogs without relationship to female sexual hormone.
Highlights
Mammary gland tumors are the most common tumors in sexually intact female dogs; they are rare in male dogs
The results of this study suggest that mammary tumors and testes tumors can occur in male dogs with‐ out relationship to female sexual hormone
There are no significant benefits of ovariohysterectomy after 4 years of age [4]. These results showed that blocking heat cycles in dogs can prevent mammary gland tumors, which suggests that ovarian hormones are important factors influencing the formation mammary gland tumors
Summary
Mammary gland tumors are the most common tumors in sexually intact female dogs; they are rare in male dogs. Conclusion: The results of this study suggest that mammary tumors and testes tumors can occur in male dogs with‐ out relationship to female sexual hormone. Background Mammary gland tumors are the most common tumors in sexually intact female dogs [1]. Most mammary gland tumors in female dogs are of epithelial origin, and approximately 50% are malignant [2, 3].
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