Abstract
In the absence of the mammary-tumor agent (MTA), breeding females of the CBA stock, observed since 1951, have remained free of spontaneous mammary cancer. After CBA young had been nursed by females of the cancerous Z (C3H) stock, to obtain the MTA, CBA breeders of the fostered and succeeding 3 generations had an incidence of 99 percent, with an average cancer age of 252 days. Because gonadectomized mice of the CBA stock developed adrenal cortical lesions, CBA males were mated with females of the A strain, which have a low incidence of mammary cancer in nonbreeders. The F1 females, maintained as virgins, showed a high incidence. These observations demonstrate that mice of the inbred CBA stock are susceptible to spontaneous mammary cancer and, in addition, transmit the mammary-cancer-inducing inherited hormonal pattern associated with postcastrational adrenal alterations.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
