Mammalian Pathogenesis and Transmission of Avian Influenza A(H7N9) Viruses, Tennessee, USA, 2017.

Jessica A Belser,Erin Hodges,Todd Davis,Joanna A Pulit-Penaloza,Joyce Jones,Nicole Brock,David Wentworth,Terrence M Tumpey,Taronna R Maines,Xiangjie Sun,Natosha Zanders

doi:10.3201/eid2401.171574

Abstract

Infections with low pathogenicity and highly pathogenic avian influenza A(H7N9) viruses affected poultry in 4 states in the southeastern United States in 2017. We evaluated pathogenicity and transmission of representative viruses in mouse and ferret models and examined replication kinetics in human respiratory tract cells. These viruses can cause respiratory infections in mammalian models.

Highlights

Infections with low pathogenicity and highly pathogenic avian influenza A(H7N9) viruses affected poultry in 4 states in the southeastern United States in 2017
We examined in 2 mammalian models the pathogenicity and transmissibility of LPAI and highly pathogenic avian influenza (HPAI) H7N9 subtype viruses isolated from chickens in Tennessee and evaluated the capacity for these viruses to replicate in a representative human respiratory cell line
Pathogenesis of Avian Influenza A(H7N9) Viruses. These findings indicate that HPAI and LPAI chickens in Tennessee (ck/TN) viruses have mild virulence for 2 mammalian species

Summary

Introduction

Infections with low pathogenicity and highly pathogenic avian influenza A(H7N9) viruses affected poultry in 4 states in the southeastern United States in 2017. Similar to previous epornitics of LPAI H7N9 subtype virus in Kentucky, Minnesota, and Nebraska in recent years, viruses isolated in Tennessee in Author affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA We examined in 2 mammalian models the pathogenicity and transmissibility of LPAI and HPAI H7N9 subtype viruses isolated from chickens in Tennessee (ck/TN) and evaluated the capacity for these viruses to replicate in a representative human respiratory cell line.

Results

Conclusion