Mammalian chemosensory receptors.

Abstract

Chemosensory receptors are critical for the survival of many mammalian species, and their genes can comprise up to 1% of mammalian genomes. Odorant, taste, and vomeronasal receptors are being discovered and functionally characterized at a rapid pace which has been further accelerated by the availability of the human genome sequence. Five multigene families, consisting of >1,000 genes in the mouse, have been proposed to encode functional chemoreceptors. Although all of the chemoreceptor gene families encode G-protein coupled receptors, they are largely unrelated and uniquely specialized for the processing of different chemosensory modalities. Using members of the families as molecular probes, great insights are being gained into the different organizational strategies used by these sensory systems to encode information in both the periphery and the brain.