Malondialdehyde and nitric oxide levels in the plasma of patients with advanced laryngeal cancer.

Abstract

We investigated alterations in plasma nitrite, nitrate, total nitric oxide (NO*), and malondialdehyde (MDA) levels in patients with advanced stage laryngeal cancer. We measured the levels of MDA and total NO2-, as well as the NO3- marker for NO* generation, in 25 patients with advanced laryngeal cancer and 15 healthy control subjects. The levels of plasma MDA, NO*, and NO3- were significantly higher in the patients with laryngeal cancer than in the healthy controls (P < 0.001 for all). On the other hand, although plasma NO2- was increased in the patient group, the statistical difference was not significant (P > 0.05). Moreover, the MDA and NO* levels did not differ significantly between patients with stage III and stage IV laryngeal cancer. These findings demonstrate that oxidative stress is increased in patients with advanced laryngeal cancer.