Abstract
Mallotus philippinensis Muell. Arg (Euphorbiaceae) are widely distributed perennial shrub or small tree in tropical and subtropical region in outer Himalayas regions with an altitude below 1,000 m and are reported to have wide range of pharmacological activities. Mallotus philippinensis species are known to contain different natural compounds, mainly phenols, diterpenoids, steroids, flavonoids, cardenolides, triterpenoids, coumarins, isocoumarins, and many more especially phenols; that is, bergenin, mallotophilippinens, rottlerin, and isorottlerin have been isolated, identified, and reported interesting biological activities such as antimicrobial, antioxidant, antiviral, cytotoxicity, antioxidant, anti-inflammatory, immunoregulatory activity protein inhibition against cancer cell. We have selected all the pharmacological aspects and toxicological and all its biological related studies. The present review reveals that Mallotus philippinensis is a valuable source of medicinally important natural molecules and provides convincing support for its future use in modern medicine. However, the existing knowledge is very limited about Mallotus philippinensis and its different parts like steam, leaf, and fruit. Further, more detailed safety data pertaining to the acute and subacute toxicity and cardio- and immunotoxicity also needs to be generated for crude extracts or its pure isolated compounds. This review underlines the interest to continue the study of this genus of the Euphorbiaceae.
Highlights
Mallotus is a large genus of trees and shrubs distributed in the tropical and subtropical regions of the Old World with around 20 species in India [1]
M. philippinensis fruit contains two new phloroglucinol derivatives, mallotophilippens A and B (Figures 10 and 11) which were identified, using chemical and spectral data, as 1-[5,7-dihydroxy-2,2-dimethyl-6-(2,4,6-trihydroxy-3-isobutyryl-5-methyl-benzyl)2H-chromen-8-yl]-2-methyl-butan-1-one and 1-[6-(3Acetyl-2,4,6-trihydroxy-5-methyl-benzyl)-5,7-dihydroxy-2,2 -dim-ethyl-2H-chromen-8-yl]-2-methyl-butan-1-one, respectively. These compounds inhibited the production of nitric oxide (NO) and inducible NO synthase gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-g (IFN-g)
Medicinal plants have been clinically used and its interest has been dramatically increased over the past decades throughout the world and its formulations are increasingly cited in media
Summary
Mallotus (family: Euphorbiaceae) is a large genus of trees and shrubs distributed in the tropical and subtropical regions of the Old World with around 20 species in India [1]. The collected material is fine, granular powder, dull red, or madder red-colored and floats on water This plant is traditionally used for antifilarial [2], antibacterial, anti-inflammatory, and immune-regulatory activity [3] and used as purgative, anthelmintic, vulnerary, detergent, maturant, carminative, alexiteric and is useful in treatment of bronchitis, abdominal diseases, spleen enlargement, antimicrobial, antiparasitic, and so forth (Figure 18). Leaves are mostly acute or acuminate at apex, conspicuously 3-nerved, hairy and reddish glandular beneath, petiole size 1–4 cm long, puberulous and reddish-brown in color (Figure 19(b)). Plants will grow mostly in a wide range of soil types, including infertile soils, limestone, acid, and rocky land
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
