Abstract
BackgroundMalignant tumours of the temporomandibular joint (MTTMJ) are extremely rare. Studies describing its unique epidemiology, clinicopathological features, treatment and prognosis comprehensively are limited. To address these issues, current investigation was performed.MethodsA retrospective research was carried out by using population-based data from the Surveillance, Epidemiology, and End Results database (1973–2016).ResultsData for a total of 734 patients, including 376 men and 358 women, was found. The median age was 47 years. The 5-year and 10-year disease specific survival (DSS) rates were 69.2 and 63.6%, respectively. Significant differences in DSS were found according to age, race, tumour type, AJCC/TNM stage, surgery, radiotherapy, chemotherapy and different treatment modalities (P < 0.05). In the multivariate survival analysis, age > 44 years and AJCC stage III and IV were associated with poor DSS.ConclusionMTTMJ was mostly found in white people with a median age of 47 years without any sex predominance. Patient’s age and AJCC stage was independent predictor of DSS.
Highlights
Malignant tumours of the temporomandibular joint (MTTMJ) are extremely rare
We identified significant differences in DDS based on age range at diagnosis (P < 0.0001), median age (P < 0.0001), race (P = 0.0091), pathological tumour type (P < 0.0001), American Joint Committee on Cancer (AJCC) T category (P < 0.0001), AJCC N category (P < 0.0001), AJCC M category (P < 0.0001), AJCC stage (P < 0.0001), surgery (P < 0.0001), radiotherapy (P < 0.0001) and chemotherapy (P = 0.0028) (Fig. 3)
For the first time, we attempted to conduct a retrospective study on the epidemiological characteristics, clinicopathologic features, treatment, survival and prognostic factors of Temporomandibular joint (TMJ) malignancy with the largest sample size
Summary
Malignant tumours of the temporomandibular joint (MTTMJ) are extremely rare. Studies describing its unique epidemiology, clinicopathological features, treatment and prognosis comprehensively are limited To address these issues, current investigation was performed. Malignant tumours of the temporomandibular joint (MTTMJ) are very rare and often cause facial asymmetry deformity and occlusal disorders [3]. MTTMJ originates from three possible sites: (a) intrinsic tissue of the TMJ, (b) extension of malignant tumours from adjacent issues, such as parotid gland malignant neoplasm, and (c) distant metastatic spread to the joint. Among these tumours, primary tumours from intrinsic tissue of the TMJ are extremely rare. The clinical manifestation and differential diagnosis of TMJ malignancies is challenging for primary care doctors [5]
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