Abstract
To investigate the incidence of malignant transformation and P53 and P16 expression in teratomatous skin of ovarian mature cystic teratoma. Data on ovarian teratoma specimens in nearly 10 years were reviewed. P53 and P16 expression were detected by immunohistochemistry in 25 cases of teratomatous skin of ovarian mature cystic teratoma, 20 cases of squamous cell carcinoma and 2 cases of squamous cell carcinoma originated from teratomatous skin. Of 1913 cases of ovarian mature cystic teratoma in nearly 10 years, only two cases of squamous cell carcinoma were found in teratomatous skin, with malignant transformation rate of 0.1045%. P53 expression was detected in 2 cases squamous cell carcinoma originated from teratomatous skin and P16 overexpression in one. There were no expressions of P53 and P16 in 25 cases of teratomatous skin of ovarian mature cystic teratoma. Of 20 cases of squamous cell carcinoma P53 overexpression (positive rate of 55%) was detected in 11 cases, P16 overexpression (positive rate of 35%) in 7 cases. The positive rates of P53 and P16 expression in squamous cell carcinomas were significantly higher than that in the teratomatous skins (p< 0.001, p= 0.002). There was low risk of malignant transformation in teratomatous skin of ovarian mature cystic teratoma which can be explained by lower P53 and P16 expressionin teratomas than that in squamous cell carcinoma.
Highlights
Teratoma is one of embryonal tumors, derived from the ectoderm, mesoderm and endoderm
P53 and P16 expression were detected by immunohistochemistry in 25 cases of teratomatous skin of ovarian mature cystic teratoma, 20 cases of squamous cell carcinoma and 2 cases of squamous cell carcinoma originated from teratomatous skin
Of 1913 cases of ovarian mature cystic teratoma in nearly 10 years, only two cases of squamous cell carcinoma were found in teratomatous skin, with malignant transformation rate of 0.1045%
Summary
Teratoma is one of embryonal tumors, derived from the ectoderm, mesoderm and endoderm. The stratified squamous epithelium, sebaceous glands, hair follicles and hair etc can be seen in the skin-like tissues of ovarian teratoma (referred to teratomatous skin of ovarian teratoma), which are similar to normal skin tissue. The teratomatous skin may occurs malignant transformation. Previous studies showed that abnormal P53 and P16 expression in a variety of tumors including ovarian cancers and squamous cell carcinoma of the skin. It was reported that abnormal P53 and P16 expression can be found in teratomatous skin with malignant transformation. This study was conducted to detect and analysis the P53 and P16 expression in the teratomatous skin of ovarian mature teratoma, squamous cell carcinoma of the skin and squamous cell carcinoma originated from the teratomatous skin
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