Malignant Transformation of the Mature Cystic Teratoma of the Ovary

Abstract

The mature cystic teratoma of ovary is most prevalent type of neoplasm of ovarian germ cells. It accounts for the almost 20% of the neoplasm. Objective: To find the malignant transformation of mature cystic teratoma of ovary. Methods: The study was conducted on the 28 patients who visited Cheikh Zayed Hospital Mauritania for the duration of six months from July 2018 to December 2018 and patients who underwent surgery related to ovarian cancer. All the patients underwent tumor marker tests to see the level of cancer antigen in their serum. The level of serum SCC antigen was also tested in all patients before carrying out any surgery. The level of CA-19-9 was also measured. CEA level to check the carcinoembryonic antigen was also carried out. Results: Among these 28, there were 15 patients that had malignant transformation from MCT. The age of patients was ranging from 28 to 74 years. The median age was 50 years. There were 9 patients that were on a post-menopausal state. There were 4 patients that were reported as nulliparous, the remaining were parous. Almost all the patients were presented with symptoms like lower abdominal pain and feeling of palpable mass in the lower abdomen. Conclusions: Malignant transformation in case of MCT is rare but it has poor prognosis. Its quick detection and proper treatment is very important. The use of surgical operation along with adjuvant treatment and chemotherapy have role in controlling the malignancy