Malignant Transformation of Perianal Giant Condyloma Acuminatum

Abstract

Giant condyloma acuminatum or Buschke-Lowenstein tumor is characterized by its large size and is prone to infiltrating into underlying tissues although it is microscopically benign. It commonly affects the genitalia. Cases of perianal giant condyloma acuminatum are reported sporadically in the English literature. In Taiwan, only one case of perianal giant condyloma acuminatum was found in literature. We report a rare case of perianal giant condyloma acuminatum in a 56-year-old, non-homosexual, married man. There was a 10-cm × 6-cm × 4-cm fungating circum-anal mass extending into his left buttock. He initially received simple excision and electrofulgaration in Sep 2004. Pathology did not reveal evidence of malignancy. However, one year later, he received wide local excision for recurrent lesion. Pathology demonstrated malignant transformation with verrucous carcinoma. Three months later, wound healed by secondary intention. After follow-up for fifteen months, no anorectal condyloma has been found with examination under anesthesia. The patient had no anal stenosis or incontinence.