Abstract
Oral Leukoplakia is one of the most common oral premalignant lesions and dened as white patch or plaque that does not rub off clinically identied as another entity. Etiological factors are smoking, viral and fungal agent and specic nutrients and deciency may have role in the development and progression. Clinically it can be classied as homogenous and non-homogenous. It most seen on buccal mucosa and lateral border of tongue. Malignant transformation of oral leukoplakia is about 5-18%. A higher chance of it transformation has been seen in non-homogeneous, high risk anatomic structures such as the oor of the mouth or the tongue, as well as a history of non-smoking. It can be diagnosed by biopsy, toluidine blue staining or lugol s iodine and exfoliative cytology. Management is surgical excision, cryosurgery, CO2 laser, retinoids, photodynamic therapy
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