Malignant Transformation of Ameloblastoma of Mandible

Abstract

The origin of ameloblastic fibrosarcoma (AFS) or ameloblastic dentinosarcoma in the background of ameloblastic fibroma has been widely reported in literature. To the best of our knowledge, the malignant transformation of a benign ameloblastoma to an aggressive variety of AFS has never been reported. Here, we report a rare case of follicular ameloblastoma of mandible in a 16-year-old female, who initially presented with a painless slow growing swelling, gradually transformed into a painful, aggressive variety of AFS requiring extensive surgery and chemoradiation therapy.