MALIGNANT THROMBOCYTOSIS PRECIPITATED BY TUBERCULOSIS

Abstract

TYPE: Abstract Publication TOPIC: Chest Infections PURPOSE: Throbocytopenia has been specifically associated with fevers like Dengue . Whereas Thrombocytosis has been thought of as a reactive hyperplasia in certain kinds of Infections when the count is less than 1 million per cubic mm. But when the platelet count has crossed the 1 million level usually we tend to diagnose either leukemia, myelopriliferative disorder or autoimmune disease. Here we report a case of Malignant Thrombocytosis that had an accidental findings in the patient's chest (tuberculous infiltration both in her lungs and pleura) Treatement with Antituberculous drugs (ATT) for two months had resulted in regression of Platelets count favourably from 10,000,00 to 2,95,000 /cmm.after 2 months. Contiued ATT for the next 4 months had resulted in complete remissionof Thrombocytosis. METHODS: Idiopathic THROMBOCYTOSIS got regressed by treatement of the associated pathology ( Tuberculosis) RESULTS: The Platelets count dropped from 1 million per cmm before treatement to less than half million in 2 months and then to normal after 6 months of tuberculous treatement CONCLUSIONS: In our clincal practice when we are faced with situations like this where the usual trend is to think in terms of auto immunity/ myeloproliferative disorders, we must first look out for common treatable conditions like tuberculosis that causes reactive hyperplasia of Megakaryocytes. CLINICAL IMPLICATIONS: When we are open to navigate our cases with an open mind to accept possible new causes that has not been traditionally recorded in text books, we can benefit our patients by unnecessairly branding them as Malignancy of the Bone Marrow and starting on Chemotheraputic or Immunosuppresants. DISCLOSURE: No significant relationships. KEYWORD: malignant thrombocytosis/ differetial diagnosis/ tuberculosis/ ATT