Abstract
Elevated levels of low density lipoprotein (LDL) are an independent risk factor for cardiovascular disease. LDL however is not a single entity but consists of a heterogeneous group of particles with smaller dense particles being the most atherogenic. To test the hypothesis that malignant hypertension (MHT), the most severe form of hypertension, is associated with an abnormal lipid profile, and that this may contribute to the complications of MHT, we studied 18 patients presenting with this condition (49.4 (11.4) years; 16 male; 236/141). LDL subfraction profile was measured by disc polyacrylamide gel electrophoresis using a validated scoring system to calculate the mean (locus) and standard deviation (spread) mobility of LDL. Results were compared with 41 patients with non-malignant, untreated hypertension (mean age 53.9 years; 24 male systolic/diastolic blood pressure 173/100) and 45 normotensive patients with normal coronary angiograms (58 (10.6) years; 22 male; 136/80).
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