Abstract
We report two cases of cutaneous malignant peripheral nerve sheath tumors. One occurred in a patient without neurofibromatosis and manifested as a recurrent scalp nodule. Histologically, the lesion began as a benign-appearing, dermal neurofibroma and progressed to a highly cellular, pleomorphic neoplasm with prominent mitotic activity and invasion of the subcutis. Immunohistochemical and ultrastructural examination confirmed the nerve sheath origin of this tumor. The other case presented as a large scalp mass in a patient with an established diagnosis of neurofibromatosis; its immunohistochemical characteristics were identical to those of case 1. Although malignant peripheral nerve sheath tumors are uncommon in the skin, they can be effectively separated from other spindle cell neoplasms by specialized pathologic studies.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
