Abstract
ABSTRACT A captive 12-year-old female maned wolf (Chrysocyon brachyurus), previously diagnosed with visceral leishmaniasis, developed severe myiasis in the right ear, followed by prostration and death. A firm solid nodule, measuring 1 x 3cm, was grossly observed in the pancreas. Histologically, there was neoplastic proliferation in the pancreas and pancreatic lymph node. Neoplastic cells had a neuroendocrine pattern, and were positive for gastrin and pancreatic polypeptide by immunohistochemistry. The wolf had also ulcerative gastritis. To the best of our knowledge is the first reported case gastrinoma in this species.
Highlights
Gastrinoma is a neuroendocrine tumor that secretes gastrin
Gastrinomas have been initially described as a neuroendocrine tumor of pancreatic origin, in humans, 40 to 60% of these tumors develop primarily in the duodenal wall, whereas only 20% involve the pancreas (Morrow and Norton, 2009)
The goal of this report is to describe a case of pancreatic gastrinoma in a 12-year-old female maned wolf (Chrysocyon brachyurus), which to the best of our knowledge is the first reported case in this species
Summary
Gastrinoma is a neuroendocrine tumor that secretes gastrin. Gastrinomas have been initially described as a neuroendocrine tumor of pancreatic origin, in humans, 40 to 60% of these tumors develop primarily in the duodenal wall, whereas only 20% involve the pancreas (Morrow and Norton, 2009). Canine and feline gastrinomas are mostly primary of the pancreatic islets (Altschul et al, 1997), with only a few reported cases that developed primarily in the duodenum (Vergine et al, 2005). Duodenal gastrinomas, in humans and dogs tend to be smaller in size, making the diagnosis in these cases more challenging (Vergine et al, 2005)
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