Abstract
We describe a rare case of malignant granulosa cell tumour in an adult ewe, euthanised due to progressive weight loss. Necropsy examination revealed a neoplastic enlargement of the right ovary, multifocal neoplastic masses in the lung and spleen, and severe enlargement of mediastinal and iliacal lymph nodes. Histopathology of the right ovary revealed a malignant ovarian granulosa cell tumour with metastases to the lung, spleen, and mediastinal and iliacal lymph nodes. Immunohistochemistry confirmed histopathological diagnosis. Neoplastic cells reacted positively for CK MNF 116 and vimentin and were negative for CK 7 and desmin. To our knowledge this is the first report of a malignant granulosa cell tumour in ewe.
Highlights
We describe a rare case of malignant granulosa cell tumour in an adult ewe, euthanised due to progressive weight loss
We describe the pathomorphologic findings in a ewe with malignant ovarian granulosa cell tumour and metastases to the spleen, lung, and mediastinal and iliacal lymph nodes
Progressive weight loss was the only clinical sign observed in our case of malignant granulosa cell tumour in a ewe, in contrast to previously described cases of these tumours e.g. in mares and a bitch where a variety of clinical signs were described, for example: lameness, udder development, lactation and anorexia (Gardner et al 2005), progressive weight loss, diarrhoea and depression (Patrick et al 2003), anorexia (Sabocanec et al 1996; Patrick et al 2003), and lameness (Gift et al 1992)
Summary
We describe a rare case of malignant granulosa cell tumour in an adult ewe, euthanised due to progressive weight loss. Histopathology of the right ovary revealed a malignant ovarian granulosa cell tumour with metastases to the lung, spleen, and mediastinal and iliacal lymph nodes. Neoplastic cells reacted positively for CK MNF 116 and vimentin and were negative for CK 7 and desmin To our knowledge this is the first report of a malignant granulosa cell tumour in ewe. Granulosa cell tumour is a type of sex cord-stromal tumour, composed primary of neoplastic granulosa cells, but often of theca cells and fibroblasts (Kennedy et al 1998) These tumours represent the most common ovarian tumours in the cow and mare; they are infrequent in the queen and rare in other domestic animals. Few cases of benign granulosa cell tumours have been described in ewes (Cordes and Shortridge 1971; McEntee 1990; Smith et al 1999; Gardner et al 2005)
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